General Structural Motifs of Amyloid Protofilaments
General Structural Motifs of Amyloid Protofilaments
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United States: National Academy of Sciences
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Language
English
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Publisher
United States: National Academy of Sciences
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Contents
Human CA150, a transcriptional activator, binds to and is codeposited with huntingtin during Huntington's disease. The second WW domain of CA150 is a three-stranded β-sheet that folds in vitro in microseconds and forms amyloid fibers under physiological conditions. We found from exhaustive alanine scanning studies that fibrillation of this WW domai...
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Full title
General Structural Motifs of Amyloid Protofilaments
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TN_cdi_pnas_primary_103_44_16248_fulltext
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_pnas_primary_103_44_16248_fulltext
Other Identifiers
ISSN
0027-8424
E-ISSN
1091-6490
DOI
10.1073/pnas.0607815103
