Mice expressing a humanized form of VEGF-A may provide insights into the safety and efficacy of anti...
Mice expressing a humanized form of VEGF-A may provide insights into the safety and efficacy of anti-VEGF antibodies
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Author / Creator
Gerber, Hans-Peter , Wu, Xiumin , Yu, Lanlan , Wiesmann, Christian , Liang, Xiao Huan , Lee, Chingwei V , Fuh, Germaine , Olsson, Christine , Damico, Lisa , Xie, David , Meng, Y. Gloria , Gutierrez, Johnny , Corpuz, Racquel , Li, Bing , Hall, Linda , Rangell, Linda , Ferrando, Ron , Lowman, Henry , Peale, Franklin and Ferrara, Napoleone
Publisher
United States: National Academy of Sciences
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Language
English
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Publisher
United States: National Academy of Sciences
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Contents
VEGF-A is important in tumor angiogenesis, and a humanized anti-VEGF-A monoclonal antibody (bevacizumab) has been approved by the FDA as a treatment for metastatic colorectal and nonsquamous, non-small-cell lung cancer in combination with chemotherapy. However, contributions of both tumor- and stromal-cell derived VEGF-A to vascularization of human...
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Full title
Mice expressing a humanized form of VEGF-A may provide insights into the safety and efficacy of anti-VEGF antibodies
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Record Identifier
TN_cdi_pnas_primary_104_9_3478_fulltext
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_pnas_primary_104_9_3478_fulltext
Other Identifiers
ISSN
0027-8424
E-ISSN
1091-6490
DOI
10.1073/pnas.0611492104
