Single treatment with RNAi against prion protein rescues early neuronal dysfunction and prolongs sur...
Single treatment with RNAi against prion protein rescues early neuronal dysfunction and prolongs survival in mice with prion disease
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United States: National Academy of Sciences
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Language
English
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United States: National Academy of Sciences
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Prion diseases are fatal neurodegenerative conditions for which there is no effective treatment. Prion propagation involves the conversion of cellular prion protein, PrPC, to its conformational isomer, PrPSc, which accumulates in disease. Here, we show effective therapeutic knockdown of PrPC expression using RNAi in mice with established prion dise...
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Single treatment with RNAi against prion protein rescues early neuronal dysfunction and prolongs survival in mice with prion disease
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TN_cdi_pnas_primary_105_29_10238_fulltext
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https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_pnas_primary_105_29_10238_fulltext
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ISSN
0027-8424
E-ISSN
1091-6490
DOI
10.1073/pnas.0802759105
