Tissue-specific PKA inhibition using a chemical genetic approach and its application to studies on s...
Tissue-specific PKA inhibition using a chemical genetic approach and its application to studies on sperm capacitation
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Publisher
United States: National Academy of Sciences
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Language
English
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Publisher
United States: National Academy of Sciences
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Contents
Studies on cAMP signaling and protein kinase A (PKA) function in vivo are limited by the lack of highly specific inhibitors that can be used in primary cell culture and whole animals. Previously we reported that a mutation in the ATP binding pocket of a catalytic subunit (Cα) of PKA confers sensitivity to the pyrazolo[3,4-d]pyrimidine inhibitor, 1N...
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Full title
Tissue-specific PKA inhibition using a chemical genetic approach and its application to studies on sperm capacitation
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TN_cdi_pnas_primary_105_52_20740
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_pnas_primary_105_52_20740
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ISSN
0027-8424
E-ISSN
1091-6490
DOI
10.1073/pnas.0810971105
