Human memory FOXP3⁺ Tregs secrete IL-17 ex vivo and constitutively express the TH17 lineage-specific...
Human memory FOXP3⁺ Tregs secrete IL-17 ex vivo and constitutively express the TH17 lineage-specific transcription factor RORγt
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Publisher
National Academy of Sciences
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Language
English
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National Academy of Sciences
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Recent studies have suggested a close relationship between CD4⁺FOXP3⁺ regulatory T cells (Tregs) and proinflammatory IL-17-producing T helper cells (TH17) expressing the lineage-specific transcription factor RORγt. We report here the unexpected finding that human memory Tregs secrete IL-17 ex vivo and constitutively express RORγt. IL-17-secreting T...
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Full title
Human memory FOXP3⁺ Tregs secrete IL-17 ex vivo and constitutively express the TH17 lineage-specific transcription factor RORγt
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TN_cdi_pnas_primary_106_21_8635
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https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_pnas_primary_106_21_8635
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ISSN
0027-8424
E-ISSN
1091-6490
DOI
10.1073/pnas.0900621106
