Structural basis for the inhibition of the essential Plasmodium falciparum M1 neutral aminopeptidase
Structural basis for the inhibition of the essential Plasmodium falciparum M1 neutral aminopeptidase
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Author / Creator
McGowan, Sheena , Porter, Corrine J , Lowther, Jonathan , Stack, Colin M , Golding, Sarah J , Skinner-Adams, Tina S , Trenholme, Katharine R , Teuscher, Franka , Donnelly, Sheila M , Grembecka, Jolanta , Mucha, Artur , Kafarski, Pawel , DeGori, Ross , Buckle, Ashley M , Gardiner, Donald L , Whisstock, James C and Dalton, John P
Publisher
United States: National Academy of Sciences
Journal title
Language
English
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Publisher
United States: National Academy of Sciences
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Contents
Plasmodium falciparum parasites are responsible for the major global disease malaria, which results in >2 million deaths each year. With the rise of drug-resistant malarial parasites, novel drug targets and lead compounds are urgently required for the development of new therapeutic strategies. Here, we address this important problem by targeting th...
Alternative Titles
Full title
Structural basis for the inhibition of the essential Plasmodium falciparum M1 neutral aminopeptidase
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Record Identifier
TN_cdi_pnas_primary_106_8_2537_fulltext
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_pnas_primary_106_8_2537_fulltext
Other Identifiers
ISSN
0027-8424
E-ISSN
1091-6490
DOI
10.1073/pnas.0807398106
