Loss of human Greatwall results in G2 arrest and multiple mitotic defects due to deregulation of the...
Loss of human Greatwall results in G2 arrest and multiple mitotic defects due to deregulation of the cyclin B-Cdc2/PP2A balance
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Publisher
United States: National Academy of Sciences
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Language
English
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United States: National Academy of Sciences
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Here we show that the functional human ortholog of Greatwall protein kinase (Gwl) is the microtubule-associated serine/threonine kinase-like protein, MAST-L. This kinase promotes mitotic entry and maintenance in human cells by inhibiting protein phosphatase 2A (PP2A), a phosphatase that dephosphorylates cyclin B-Cdc2 substrates. The complete deplet...
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Full title
Loss of human Greatwall results in G2 arrest and multiple mitotic defects due to deregulation of the cyclin B-Cdc2/PP2A balance
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TN_cdi_pnas_primary_107_28_12564
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_pnas_primary_107_28_12564
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ISSN
0027-8424
E-ISSN
1091-6490
DOI
10.1073/pnas.0914191107
