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Mycobacterium tuberculosis Eis protein initiates suppression of host immune responses by acetylation...

Mycobacterium tuberculosis Eis protein initiates suppression of host immune responses by acetylation...

https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_pnas_primary_109_20_7729

Mycobacterium tuberculosis Eis protein initiates suppression of host immune responses by acetylation of DUSP16/MKP-7

About this item

Full title

Mycobacterium tuberculosis Eis protein initiates suppression of host immune responses by acetylation of DUSP16/MKP-7

Publisher

United States: National Academy of Sciences

Journal title

Proceedings of the National Academy of Sciences - PNAS, 2012-05, Vol.109 (20), p.7729-7734

Language

English

Formats

Publication information

Publisher

United States: National Academy of Sciences

More information

Scope and Contents

Contents

The intracellular pathogen Mycobacterium tuberculosis (Mtb) causes tuberculosis. Enhanced intracellular survival (Eis) protein, secreted by Mtb. enhances survival of Mycobacterium smegmatis (Msm) in macrophages. Mtb Eis was shown to suppress host immune defenses by negatively modulating autophagy, inflammation, and cell death through JNK-dependent...

Alternative Titles

Full title

Mycobacterium tuberculosis Eis protein initiates suppression of host immune responses by acetylation of DUSP16/MKP-7

Identifiers

Primary Identifiers

Record Identifier

TN_cdi_pnas_primary_109_20_7729

Permalink

https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_pnas_primary_109_20_7729

Other Identifiers

ISSN

0027-8424

E-ISSN

1091-6490

DOI

10.1073/pnas.1120251109

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