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Cis- and trans-membrane interactions of synaptotagmin-1

Cis- and trans-membrane interactions of synaptotagmin-1

https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_pnas_primary_109_27_11037

Cis- and trans-membrane interactions of synaptotagmin-1

About this item

Full title

Cis- and trans-membrane interactions of synaptotagmin-1

Publisher

United States: National Academy of Sciences

Journal title

Proceedings of the National Academy of Sciences - PNAS, 2012-07, Vol.109 (27), p.11037-11042

Language

English

Formats

Publication information

Publisher

United States: National Academy of Sciences

More information

Scope and Contents

Contents

In neurotransmission synaptotagmin-1 tethers synaptic vesicles to the presynaptic plasma membrane by binding to acidic membrane lipids and SNAREs and promotes rapid SNARE-mediated fusion upon Ca ²⁺ triggering. However, recent studies suggested that upon membrane contact synaptotagmin may not only bind in trans to the target membrane but also in cis...

Alternative Titles

Full title

Cis- and trans-membrane interactions of synaptotagmin-1

Identifiers

Primary Identifiers

Record Identifier

TN_cdi_pnas_primary_109_27_11037

Permalink

https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_pnas_primary_109_27_11037

Other Identifiers

ISSN

0027-8424

E-ISSN

1091-6490

DOI

10.1073/pnas.1116326109

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