Astrocyte dysfunction triggers neurodegeneration in a lysosomal storage disorder
Astrocyte dysfunction triggers neurodegeneration in a lysosomal storage disorder
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United States: National Academy of Sciences
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Language
English
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United States: National Academy of Sciences
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Contents
The role of astrocytes in neurodegenerative processes is increasingly appreciated. Here we investigated the contribution of astrocytes to neurodegeneration in multiple sulfatase deficiency (MSD), a severe lysosomal storage disorder caused by mutations in the sulfatase modifying factor 1 (SUMF1) gene. Using Cre/Lox mouse models, we found that astroc...
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Astrocyte dysfunction triggers neurodegeneration in a lysosomal storage disorder
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TN_cdi_pnas_primary_109_35_E2334
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_pnas_primary_109_35_E2334
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ISSN
0027-8424
E-ISSN
1091-6490
DOI
10.1073/pnas.1209577109