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Astrocyte dysfunction triggers neurodegeneration in a lysosomal storage disorder

Astrocyte dysfunction triggers neurodegeneration in a lysosomal storage disorder

https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_pnas_primary_109_35_E2334

Astrocyte dysfunction triggers neurodegeneration in a lysosomal storage disorder

About this item

Full title

Astrocyte dysfunction triggers neurodegeneration in a lysosomal storage disorder

Publisher

United States: National Academy of Sciences

Journal title

Proceedings of the National Academy of Sciences - PNAS, 2012-08, Vol.109 (35), p.E2334-E2342

Language

English

Formats

Publication information

Publisher

United States: National Academy of Sciences

More information

Scope and Contents

Contents

The role of astrocytes in neurodegenerative processes is increasingly appreciated. Here we investigated the contribution of astrocytes to neurodegeneration in multiple sulfatase deficiency (MSD), a severe lysosomal storage disorder caused by mutations in the sulfatase modifying factor 1 (SUMF1) gene. Using Cre/Lox mouse models, we found that astroc...

Alternative Titles

Full title

Astrocyte dysfunction triggers neurodegeneration in a lysosomal storage disorder

Authors, Artists and Contributors

Identifiers

Primary Identifiers

Record Identifier

TN_cdi_pnas_primary_109_35_E2334

Permalink

https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_pnas_primary_109_35_E2334

Other Identifiers

ISSN

0027-8424

E-ISSN

1091-6490

DOI

10.1073/pnas.1209577109

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