Membrane lipid saturation activates endoplasmic reticulum unfolded protein response transducers thro...
Membrane lipid saturation activates endoplasmic reticulum unfolded protein response transducers through their transmembrane domains
About this item
Full title
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Publisher
United States: National Academy of Sciences
Journal title
Language
English
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Publication information
Publisher
United States: National Academy of Sciences
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Scope and Contents
Contents
Endoplasmic reticulum (ER) stress sensors use a related luminal domain to monitor the unfolded protein load and convey the signal to downstream effectors, signaling an unfolded protein response (UPR) that maintains compartment-specific protein folding homeostasis. Surprisingly, perturbation of cellular lipid composition also activates the UPR, with...
Alternative Titles
Full title
Membrane lipid saturation activates endoplasmic reticulum unfolded protein response transducers through their transmembrane domains
Authors, Artists and Contributors
Author / Creator
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Record Identifier
TN_cdi_pnas_primary_110_12_4628
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_pnas_primary_110_12_4628
Other Identifiers
ISSN
0027-8424
E-ISSN
1091-6490
DOI
10.1073/pnas.1217611110
