Monovalent antibody design and mechanism of action of onartuzumab, a MET antagonist with anti-tumor...
Monovalent antibody design and mechanism of action of onartuzumab, a MET antagonist with anti-tumor activity as a therapeutic agent
About this item
Full title
Author / Creator
Merchant, Mark , Ma, Xiaolei , Maun, Henry R , Zheng, Zhong , Peng, Jing , Romero, Mally , Huang, Arthur , Yang, Nai-ying , Nishimura, Merry , Greve, Joan , Santell, Lydia , Zhang, Yu-Wen , Su, Yanli , Kaufman, Dafna W , Billeci, Karen L , Mai, Elaine , Moffat, Barbara , Lim, Amy , Duenas, Eileen T , Phillips, Heidi S , Xiang, Hong , Young, Judy C , Vande Woude, George F , Dennis, Mark S , Reilly, Dorothea E , Schwall, Ralph H , Starovasnik, Melissa A , Lazarus, Robert A and Yansura, Daniel G
Publisher
United States: National Academy of Sciences
Journal title
Language
English
Formats
Publication information
Publisher
United States: National Academy of Sciences
Subjects
More information
Scope and Contents
Contents
Binding of hepatocyte growth factor (HGF) to the receptor tyrosine kinase MET is implicated in the malignant process of multiple cancers, making disruption of this interaction a promising therapeutic strategy. However, targeting MET with bivalent antibodies can mimic HGF agonism via receptor dimerization. To address this limitation, we have develop...
Alternative Titles
Full title
Monovalent antibody design and mechanism of action of onartuzumab, a MET antagonist with anti-tumor activity as a therapeutic agent
Authors, Artists and Contributors
Author / Creator
Ma, Xiaolei
Maun, Henry R
Zheng, Zhong
Peng, Jing
Romero, Mally
Huang, Arthur
Yang, Nai-ying
Nishimura, Merry
Greve, Joan
Santell, Lydia
Zhang, Yu-Wen
Su, Yanli
Kaufman, Dafna W
Billeci, Karen L
Mai, Elaine
Moffat, Barbara
Lim, Amy
Duenas, Eileen T
Phillips, Heidi S
Xiang, Hong
Young, Judy C
Vande Woude, George F
Dennis, Mark S
Reilly, Dorothea E
Schwall, Ralph H
Starovasnik, Melissa A
Lazarus, Robert A
Yansura, Daniel G
Identifiers
Primary Identifiers
Record Identifier
TN_cdi_pnas_primary_110_32_E2987
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_pnas_primary_110_32_E2987
Other Identifiers
ISSN
0027-8424
E-ISSN
1091-6490
DOI
10.1073/pnas.1302725110
