Structures of a Na⁺-coupled, substrate-bound MATE multidrug transporter
Structures of a Na⁺-coupled, substrate-bound MATE multidrug transporter
About this item
Full title
Author / Creator
Publisher
United States: National Academy of Sciences
Journal title
Language
English
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Publication information
Publisher
United States: National Academy of Sciences
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More information
Scope and Contents
Contents
Multidrug transporters belonging to the multidrug and toxic compound extrusion (MATE) family expel dissimilar lipophilic and cationic drugs across cell membranes by dissipating a preexisting Na ⁺ or H ⁺ gradient. Despite its clinical relevance, the transport mechanism of MATE proteins remains poorly understood, largely owing to a lack of structural...
Alternative Titles
Full title
Structures of a Na⁺-coupled, substrate-bound MATE multidrug transporter
Authors, Artists and Contributors
Author / Creator
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Primary Identifiers
Record Identifier
TN_cdi_pnas_primary_110_6_2099
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_pnas_primary_110_6_2099
Other Identifiers
ISSN
0027-8424
E-ISSN
1091-6490
DOI
10.1073/pnas.1219901110
