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Arginine starvation-associated atypical cellular death involves mitochondrial dysfunction, nuclear D...

Arginine starvation-associated atypical cellular death involves mitochondrial dysfunction, nuclear D...

https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_pnas_primary_111_39_14147

Arginine starvation-associated atypical cellular death involves mitochondrial dysfunction, nuclear DNA leakage, and chromatin autophagy

About this item

Full title

Arginine starvation-associated atypical cellular death involves mitochondrial dysfunction, nuclear DNA leakage, and chromatin autophagy

Publisher

United States: National Academy of Sciences

Journal title

Proceedings of the National Academy of Sciences - PNAS, 2014-09, Vol.111 (39), p.14147-14152

Language

English

Formats

Publication information

Publisher

United States: National Academy of Sciences

More information

Scope and Contents

Contents

Significance Nutritional starvation therapy is under intensive investigation because it provides a potentially lower toxicity with higher specificity than conventional cancer therapy. Autophagy, often triggered by starvation, represents an energy-saving, pro-survival cellular function; however, dysregulated autophagy could also lead to cell death,...

Alternative Titles

Full title

Arginine starvation-associated atypical cellular death involves mitochondrial dysfunction, nuclear DNA leakage, and chromatin autophagy

Identifiers

Primary Identifiers

Record Identifier

TN_cdi_pnas_primary_111_39_14147

Permalink

https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_pnas_primary_111_39_14147

Other Identifiers

ISSN

0027-8424

E-ISSN

1091-6490

DOI

10.1073/pnas.1404171111

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