Characterization of the complex formed by β-glucocerebrosidase and the lysosomal integral membrane p...
Characterization of the complex formed by β-glucocerebrosidase and the lysosomal integral membrane protein type-2
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Publisher
United States: National Academy of Sciences
Journal title
Language
English
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Publisher
United States: National Academy of Sciences
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Contents
The lysosomal integral membrane protein type-2 (LIMP-2) plays a pivotal role in the delivery of β-glucocerebrosidase (GC) to lysosomes. Mutations in GC result in Gaucher’s disease (GD) and are the major genetic risk factor for the development of Parkinson’s disease (PD). Variants in the LIMP-2 gene cause action myoclonus-renal failure syndrome and...
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Full title
Characterization of the complex formed by β-glucocerebrosidase and the lysosomal integral membrane protein type-2
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TN_cdi_pnas_primary_113_14_3791
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_pnas_primary_113_14_3791
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ISSN
0027-8424
E-ISSN
1091-6490
DOI
10.1073/pnas.1514005113
