Two Amyloid Precursor Protein Transgenic Mouse Models with Alzheimer Disease-Like Pathology
Two Amyloid Precursor Protein Transgenic Mouse Models with Alzheimer Disease-Like Pathology
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Author / Creator
Sturchler-Pierrat, Christine , Abramowski, Dorothee , Duke, Mairead , Wiederhold, Karl-Heinz , Mistl, Claudia , Rothacher, Sabin , Ledermann, Brigit , Bürki, Kurt , Frey, Peter , Paganetti, Paolo A. , Waridel, Caroline , Calhoun, Michael E. , Jucker, Mathias , Probst, Alphonse , Staufenbiel, Matthias and Sommer, Bernd
Publisher
United States: National Academy of Sciences of the United States of America
Journal title
Language
English
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Publisher
United States: National Academy of Sciences of the United States of America
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Scope and Contents
Contents
Mutations in the amyloid precursor protein (APP) gene cause early-onset familial Alzheimer disease (AD) by affecting the formation of the amyloid β (Aβ ) peptide, the major constituent of AD plaques. We expressed human APP751 containing these mutations in the brains of transgenic mice. Two transgenic mouse lines develop pathological features remini...
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Full title
Two Amyloid Precursor Protein Transgenic Mouse Models with Alzheimer Disease-Like Pathology
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Author / Creator
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Record Identifier
TN_cdi_pnas_primary_94_24_13287
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_pnas_primary_94_24_13287
Other Identifiers
ISSN
0027-8424
E-ISSN
1091-6490
DOI
10.1073/pnas.94.24.13287
