Fiber Diffraction of Synthetic α -synuclein Filaments Shows Amyloid-Like Cross-β Conformation
Fiber Diffraction of Synthetic α -synuclein Filaments Shows Amyloid-Like Cross-β Conformation
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United States: National Academy of Sciences of the United States of America
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English
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United States: National Academy of Sciences of the United States of America
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Contents
Filamentous inclusions made of α -synuclein constitute the defining neuropathological characteristic of Parkinson's disease, dementia with Lewy bodies, and multiple system atrophy. Rare familial cases of Parkinson's disease are associated with mutations A53T and A30P in α -synuclein. We report here the assembly properties and secondary structure ch...
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Full title
Fiber Diffraction of Synthetic α -synuclein Filaments Shows Amyloid-Like Cross-β Conformation
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TN_cdi_pnas_primary_97_9_4897_fulltext
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https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_pnas_primary_97_9_4897_fulltext
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ISSN
0027-8424
E-ISSN
1091-6490
DOI
10.1073/pnas.97.9.4897
