Myc Represses the p21(WAF1/CIP1)Promoter and Interacts with Sp1/Sp3
Myc Represses the p21(WAF1/CIP1)Promoter and Interacts with Sp1/Sp3
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Publisher
United States: National Academy of Sciences
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Language
English
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Publisher
United States: National Academy of Sciences
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Contents
The cyclin-dependent kinase inhibitor p21(WAF1/CIP1)inhibits proliferation both in vitro and in vivo, and overexpression of p21 in normal and tumor cell lines results in cell cycle arrest. In contrast, ectopic expression of Myc alleviates G1cell cycle arrest. Recent studies showed that Myc can repress p21 transcription, thereby overriding a p21-med...
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Full title
Myc Represses the p21(WAF1/CIP1)Promoter and Interacts with Sp1/Sp3
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TN_cdi_pnas_primary_98_8_4510_fulltext
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_pnas_primary_98_8_4510_fulltext
Other Identifiers
ISSN
0027-8424
E-ISSN
1091-6490
DOI
10.1073/pnas.081074898
