Dysregulated T Helper Cell Differentiation in the Absence of Interferon Regulatory Factor 4
Dysregulated T Helper Cell Differentiation in the Absence of Interferon Regulatory Factor 4
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Publisher
United States: National Academy of Sciences
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Language
English
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Publisher
United States: National Academy of Sciences
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Contents
Certain IFN regulatory factor (IRF) transcription factors indirectly influence T helper (Th) cell differentiation by regulating the production of IL-12. Here, we show that IRF4 directly regulates Th cell differentiation in vitro and in vivo during murine leishmaniasis. In the absence of IRF4, IL-12-induced Th1 cell differentiation was compromised,...
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Full title
Dysregulated T Helper Cell Differentiation in the Absence of Interferon Regulatory Factor 4
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Record Identifier
TN_cdi_pnas_primary_99_18_11808_fulltext
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_pnas_primary_99_18_11808_fulltext
Other Identifiers
ISSN
0027-8424
E-ISSN
1091-6490
DOI
10.1073/pnas.182425099
