Integrating PBPK Modeling and Organ-on-a-Chip Systems to Inform Drug Development
Integrating PBPK Modeling and Organ-on-a-Chip Systems to Inform Drug Development
Integrating PBPK Modeling and Organ-on-a-Chip Systems to Inform Drug Development
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Publisher
United States: CRC Press
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Language
English
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Publisher
United States: CRC Press
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Contents
A successful application of physiologically based pharmacokinetic (PBPK) models for the simulation and prediction of human PK is highly dependent on the quality of the in vitro input data. PBPK combines system parameters (e.g., blood flow rate, tissue volumes, and enzyme expression), and experimental drug parameters (e.g., solubility, intestinal pe...
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Full title
Integrating PBPK Modeling and Organ-on-a-Chip Systems to Inform Drug Development
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TN_cdi_proquest_ebookcentralchapters_31348756_21_310
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_proquest_ebookcentralchapters_31348756_21_310
Other Identifiers
ISBN
0367468875,9781032773483,9780367468873,1032773480
DOI
10.1201/9781003031802-13
