The mechanism of [gamma]-Secretase dysfunction in familial Alzheimer disease
The mechanism of [gamma]-Secretase dysfunction in familial Alzheimer disease
About this item
Full title
Author / Creator
Chávez-gutiérrez, Lucía , Bammens, Leen , Benilova, Iryna , Vandersteen, Annelies , Benurwar, Manasi , Borgers, Marianne , Lismont, Sam , Zhou, Lujia , Van Cleynenbreugel, Simon , Esselmann, Hermann , Wiltfang, Jens , Serneels, Lutgarde , Karran, Eric , Gijsen, Harrie , Schymkowitz, Joost , Rousseau, Frederic , Broersen, Kerensa and De Strooper, Bart
Publisher
New York: Springer Nature B.V
Journal title
Language
English
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Publication information
Publisher
New York: Springer Nature B.V
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Scope and Contents
Contents
The mechanisms by which mutations in the presenilins (PSEN) or the amyloid precursor protein (APP) genes cause familial Alzheimer disease (FAD) are controversial. FAD mutations increase the release of amyloid β (Aβ)42 relative to Aβ40 by an unknown, possibly gain-of-toxic-function, mechanism. However, many PSEN mutations paradoxically impair γ-secr...
Alternative Titles
Full title
The mechanism of [gamma]-Secretase dysfunction in familial Alzheimer disease
Authors, Artists and Contributors
Author / Creator
Bammens, Leen
Benilova, Iryna
Vandersteen, Annelies
Benurwar, Manasi
Borgers, Marianne
Lismont, Sam
Zhou, Lujia
Van Cleynenbreugel, Simon
Esselmann, Hermann
Wiltfang, Jens
Serneels, Lutgarde
Karran, Eric
Gijsen, Harrie
Schymkowitz, Joost
Rousseau, Frederic
Broersen, Kerensa
De Strooper, Bart
Identifiers
Primary Identifiers
Record Identifier
TN_cdi_proquest_journals_1018694669
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_proquest_journals_1018694669
Other Identifiers
ISSN
0261-4189
E-ISSN
1460-2075
DOI
10.1038/emboj.2012.79
