A common BIM deletion polymorphism mediates intrinsic resistance and inferior responses to tyrosine...
A common BIM deletion polymorphism mediates intrinsic resistance and inferior responses to tyrosine kinase inhibitors in cancer
About this item
Full title
Author / Creator
Ng, King Pan , Hillmer, Axel M , Chuah, Charles T H , Juan, Wen Chun , Ko, Tun Kiat , Teo, Audrey S M , Ariyaratne, Pramila N , Takahashi, Naoto , Sawada, Kenichi , Fei, Yao , Soh, Sheila , Lee, Wah Heng , Huang, John W J , Allen, John C , Woo, Xing Yi , Nagarajan, Niranjan , Kumar, Vikrant , Thalamuthu, Anbupalam , Poh, Wan Ting , Ang, Ai Leen , Mya, Hae Tha , How, Gee Fung , Yang, Li Yi , Koh, Liang Piu , Chowbay, Balram , Chang, Chia-Tien , Nadarajan, Veera S , Chng, Wee Joo , Than, Hein , Lim, Lay Cheng , Goh, Yeow Tee , Zhang, Shenli , Poh, Dianne , Tan, Patrick , Seet, Ju-Ee , Ang, Mei-Kim , Chau, Noan-Minh , Ng, Quan-Sing , Tan, Daniel S W , Soda, Manabu , Isobe, Kazutoshi , Nöthen, Markus M , Wong, Tien Y , Shahab, Atif , Ruan, Xiaoan , Cacheux-Rataboul, Valère , Sung, Wing-Kin , Tan, Eng Huat , Yatabe, Yasushi , Mano, Hiroyuki , Soo, Ross A , Chin, Tan Min , Lim, Wan-Teck , Ruan, Yijun and Ong, S Tiong
Publisher
New York: Nature Publishing Group US
Journal title
Language
English
Formats
Publication information
Publisher
New York: Nature Publishing Group US
Subjects
More information
Scope and Contents
Contents
Intrinsic resistance to tyrosine kinase inhibitor (TKI) drugs is limiting the progress of targeted cancer therapies. The efficacy of TKIs relies on their inhibition of oncogenic signaling but also on the induction of apoptosis in cancer cells, driven by activation of pro-apoptotic BIM proteins. The authors identify a germline BIM polymorphism commo...
Alternative Titles
Full title
A common BIM deletion polymorphism mediates intrinsic resistance and inferior responses to tyrosine kinase inhibitors in cancer
Authors, Artists and Contributors
Author / Creator
Hillmer, Axel M
Chuah, Charles T H
Juan, Wen Chun
Ko, Tun Kiat
Teo, Audrey S M
Ariyaratne, Pramila N
Takahashi, Naoto
Sawada, Kenichi
Fei, Yao
Soh, Sheila
Lee, Wah Heng
Huang, John W J
Allen, John C
Woo, Xing Yi
Nagarajan, Niranjan
Kumar, Vikrant
Thalamuthu, Anbupalam
Poh, Wan Ting
Ang, Ai Leen
Mya, Hae Tha
How, Gee Fung
Yang, Li Yi
Koh, Liang Piu
Chowbay, Balram
Chang, Chia-Tien
Nadarajan, Veera S
Chng, Wee Joo
Than, Hein
Lim, Lay Cheng
Goh, Yeow Tee
Zhang, Shenli
Poh, Dianne
Tan, Patrick
Seet, Ju-Ee
Ang, Mei-Kim
Chau, Noan-Minh
Ng, Quan-Sing
Tan, Daniel S W
Soda, Manabu
Isobe, Kazutoshi
Nöthen, Markus M
Wong, Tien Y
Shahab, Atif
Ruan, Xiaoan
Cacheux-Rataboul, Valère
Sung, Wing-Kin
Tan, Eng Huat
Yatabe, Yasushi
Mano, Hiroyuki
Soo, Ross A
Chin, Tan Min
Lim, Wan-Teck
Ruan, Yijun
Ong, S Tiong
Identifiers
Primary Identifiers
Record Identifier
TN_cdi_proquest_journals_1019031709
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_proquest_journals_1019031709
Other Identifiers
ISSN
1078-8956
E-ISSN
1546-170X
DOI
10.1038/nm.2713
