Inhibition of Phosphodiesterase Type 4 Decreases Stress-Induced Defecation in Rats and Mice
Inhibition of Phosphodiesterase Type 4 Decreases Stress-Induced Defecation in Rats and Mice
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Basel, Switzerland: S. Karger AG
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Language
English
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Publisher
Basel, Switzerland: S. Karger AG
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Background/Aims: Phosphodiesterase type 4 (PDE4) has been previously shown to regulate colonic contractile activity in vitro. In this study, the effects of PDE4 inhibition were assessed in a model of stress-induced defecation previously demonstrated to be due to increased colonic transit/evacuation. Methods: Rats were individually placed in a mild...
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Full title
Inhibition of Phosphodiesterase Type 4 Decreases Stress-Induced Defecation in Rats and Mice
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TN_cdi_proquest_journals_1094536431
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https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_proquest_journals_1094536431
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ISSN
0031-7012
E-ISSN
1423-0313
DOI
10.1159/000107662
