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Inhibition of Phosphodiesterase Type 4 Decreases Stress-Induced Defecation in Rats and Mice

Inhibition of Phosphodiesterase Type 4 Decreases Stress-Induced Defecation in Rats and Mice

https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_proquest_journals_1094536431

Inhibition of Phosphodiesterase Type 4 Decreases Stress-Induced Defecation in Rats and Mice

About this item

Full title

Inhibition of Phosphodiesterase Type 4 Decreases Stress-Induced Defecation in Rats and Mice

Publisher

Basel, Switzerland: S. Karger AG

Journal title

Pharmacology, 2008-01, Vol.81 (1), p.11-17

Language

English

Formats

Publication information

Publisher

Basel, Switzerland: S. Karger AG

More information

Scope and Contents

Contents

Background/Aims: Phosphodiesterase type 4 (PDE4) has been previously shown to regulate colonic contractile activity in vitro. In this study, the effects of PDE4 inhibition were assessed in a model of stress-induced defecation previously demonstrated to be due to increased colonic transit/evacuation. Methods: Rats were individually placed in a mild...

Alternative Titles

Full title

Inhibition of Phosphodiesterase Type 4 Decreases Stress-Induced Defecation in Rats and Mice

Identifiers

Primary Identifiers

Record Identifier

TN_cdi_proquest_journals_1094536431

Permalink

https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_proquest_journals_1094536431

Other Identifiers

ISSN

0031-7012

E-ISSN

1423-0313

DOI

10.1159/000107662

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