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Asn^sup 27^ is Essential for the Neurotoxicity of Amyloid [beta](1-42) Peptide

Asn^sup 27^ is Essential for the Neurotoxicity of Amyloid [beta](1-42) Peptide

https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_proquest_journals_1113684367

Asn^sup 27^ is Essential for the Neurotoxicity of Amyloid [beta](1-42) Peptide

About this item

Full title

Asn^sup 27^ is Essential for the Neurotoxicity of Amyloid [beta](1-42) Peptide

Publisher

Dordrecht: Springer Nature B.V

Journal title

International journal of peptide research and therapeutics, 2012-12, Vol.18 (4), p.341

Language

English

Formats

Publication information

Publisher

Dordrecht: Springer Nature B.V

More information

Scope and Contents

Contents

In contrast to the general tendency of hydrophobicity-toxicity relationship of amyloid β peptide, we have previously found that the replacement of Asn^sup 27^ of amyloid β(25-35) peptide with Ala yielded a more hydrophobic but less toxic analog and that of Met^sup 35^ gave a less hydrophobic but more toxic one. To reveal the unique role of these tw...

Alternative Titles

Full title

Asn^sup 27^ is Essential for the Neurotoxicity of Amyloid [beta](1-42) Peptide

Authors, Artists and Contributors

Identifiers

Primary Identifiers

Record Identifier

TN_cdi_proquest_journals_1113684367

Permalink

https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_proquest_journals_1113684367

Other Identifiers

ISSN

1573-3149

E-ISSN

1573-3904

DOI

10.1007/s10989-012-9310-3

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