Diminishing returns and tradeoffs constrain the laboratory optimization of an enzyme
Diminishing returns and tradeoffs constrain the laboratory optimization of an enzyme
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London: Nature Publishing Group UK
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English
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London: Nature Publishing Group UK
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Optimization processes, such as evolution, are constrained by diminishing returns—the closer the optimum, the smaller the benefit per mutation, and by tradeoffs—improvement of one property at the cost of others. However, the magnitude and molecular basis of these parameters, and their effect on evolutionary transitions, remain unknown. Here we purs...
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Diminishing returns and tradeoffs constrain the laboratory optimization of an enzyme
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TN_cdi_proquest_journals_1247481965
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https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_proquest_journals_1247481965
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ISSN
2041-1723
E-ISSN
2041-1723
DOI
10.1038/ncomms2246
