Selective class IIa histone deacetylase inhibition via a nonchelating zinc-binding group
Selective class IIa histone deacetylase inhibition via a nonchelating zinc-binding group
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Author / Creator
Lobera, Mercedes , Madauss, Kevin P , Pohlhaus, Denise T , Wright, Quentin G , Trocha, Mark , Schmidt, Darby R , Baloglu, Erkan , Trump, Ryan P , Head, Martha S , Hofmann, Glenn A , Murray-Thompson, Monique , Schwartz, Benjamin , Chakravorty, Subhas , Wu, Zining , Mander, Palwinder K , Kruidenier, Laurens , Reid, Robert A , Burkhart, William , Turunen, Brandon J , Rong, James X , Wagner, Craig , Moyer, Mary B , Wells, Carrow , Hong, Xuan , Moore, John T , Williams, Jon D , Soler, Dulce , Ghosh, Shomir and Nolan, Michael A
Publisher
New York: Nature Publishing Group US
Journal title
Language
English
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Publication information
Publisher
New York: Nature Publishing Group US
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Scope and Contents
Contents
Class IIa histone deacetylases (HDACs) are generally viewed as noncatalytic readers of acetylated lysines within proteins. Specific inhibitors of class IIa HDACs, based on a new zinc-binding scaffold, offer chemical probes to explore the biological function and potential druggability of this enzyme subclass.
In contrast to studies on class I his...
Alternative Titles
Full title
Selective class IIa histone deacetylase inhibition via a nonchelating zinc-binding group
Authors, Artists and Contributors
Author / Creator
Madauss, Kevin P
Pohlhaus, Denise T
Wright, Quentin G
Trocha, Mark
Schmidt, Darby R
Baloglu, Erkan
Trump, Ryan P
Head, Martha S
Hofmann, Glenn A
Murray-Thompson, Monique
Schwartz, Benjamin
Chakravorty, Subhas
Wu, Zining
Mander, Palwinder K
Kruidenier, Laurens
Reid, Robert A
Burkhart, William
Turunen, Brandon J
Rong, James X
Wagner, Craig
Moyer, Mary B
Wells, Carrow
Hong, Xuan
Moore, John T
Williams, Jon D
Soler, Dulce
Ghosh, Shomir
Nolan, Michael A
Identifiers
Primary Identifiers
Record Identifier
TN_cdi_proquest_journals_1328376933
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_proquest_journals_1328376933
Other Identifiers
ISSN
1552-4450
E-ISSN
1552-4469
DOI
10.1038/nchembio.1223
