The Drosophila orthologue of progeroid human WRN exonuclease, DmWRNexo, cleaves replication substrat...
The Drosophila orthologue of progeroid human WRN exonuclease, DmWRNexo, cleaves replication substrates but is inhibited by uracil or abasic sites: Analysis of DmWRNexo activity in vitro
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Publisher
Dordrecht: Springer Netherlands
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Language
English
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Publisher
Dordrecht: Springer Netherlands
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Werner syndrome (WS) is a rare late-onset premature ageing disease showing many of the phenotypes associated with normal ageing, and provides one of the best models for investigating cellular pathways that lead to normal ageing. WS is caused by mutation of
WRN
, which encodes a multifunctional DNA replication and repair helicase/exonuclease....
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Full title
The Drosophila orthologue of progeroid human WRN exonuclease, DmWRNexo, cleaves replication substrates but is inhibited by uracil or abasic sites: Analysis of DmWRNexo activity in vitro
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TN_cdi_proquest_journals_1346193031
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_proquest_journals_1346193031
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ISSN
0161-9152,2509-2715
E-ISSN
1574-4647,2509-2723
DOI
10.1007/s11357-012-9411-0
