Transitions to catalytically inactive conformations in EGFR kinase
Transitions to catalytically inactive conformations in EGFR kinase
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Publisher
United States: National Academy of Sciences
Journal title
Language
English
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Publisher
United States: National Academy of Sciences
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Scope and Contents
Contents
The epidermal growth factor receptor (EGFR) is a key protein in cellular signaling, and its kinase domain (EGFR kinase) is an intensely pursued target of small-molecule drugs. Although both catalytically active and inactive conformations of EGFR kinase have been resolved crystallographically, experimental characterization of the transitions between...
Alternative Titles
Full title
Transitions to catalytically inactive conformations in EGFR kinase
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Record Identifier
TN_cdi_proquest_journals_1348165425
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_proquest_journals_1348165425
Other Identifiers
ISSN
0027-8424
E-ISSN
1091-6490
DOI
10.1073/pnas.1220843110
