Identification of a small molecule with activity against drug-resistant and persistent tuberculosis
Identification of a small molecule with activity against drug-resistant and persistent tuberculosis
About this item
Full title
Author / Creator
Wang, Feng , Sambandan, Dhinakaran , Halder, Rajkumar , Wang, Jianing , Batt, Sarah M , Weinrick, Brian , Ahmad, Insha , Yang, Pengyu , Zhang, Yong , Kim, John , Hassani, Morad , Huszar, Stanislav , Trefzer, Claudia , Ma, Zhenkun , Kaneko, Takushi , Mdluli, Khisi E , Franzblau, Scott , Chatterjee, Arnab K , Johnsson, Kai , Johnson, Kai , Mikusova, Katarina , Besra, Gurdyal S , Fütterer, Klaus , Robbins, Scott H , Barnes, S Whitney , Walker, John R , Jacobs, Jr, William R and Schultz, Peter G
Publisher
United States: National Academy of Sciences
Journal title
Language
English
Formats
Publication information
Publisher
United States: National Academy of Sciences
Subjects
More information
Scope and Contents
Contents
A cell-based phenotypic screen for inhibitors of biofilm formation in mycobacteria identified the small molecule TCA1, which has bactericidal activity against both drug-susceptible and -resistant Mycobacterium tuberculosis (Mtb) and sterilizes Mtb in vitro combined with rifampicin or isoniazid. In addition, TCA1 has bactericidal activity against no...
Alternative Titles
Full title
Identification of a small molecule with activity against drug-resistant and persistent tuberculosis
Authors, Artists and Contributors
Author / Creator
Sambandan, Dhinakaran
Halder, Rajkumar
Wang, Jianing
Batt, Sarah M
Weinrick, Brian
Ahmad, Insha
Yang, Pengyu
Zhang, Yong
Kim, John
Hassani, Morad
Huszar, Stanislav
Trefzer, Claudia
Ma, Zhenkun
Kaneko, Takushi
Mdluli, Khisi E
Franzblau, Scott
Chatterjee, Arnab K
Johnsson, Kai
Johnson, Kai
Mikusova, Katarina
Besra, Gurdyal S
Fütterer, Klaus
Robbins, Scott H
Barnes, S Whitney
Walker, John R
Jacobs, Jr, William R
Schultz, Peter G
Identifiers
Primary Identifiers
Record Identifier
TN_cdi_proquest_journals_1399197097
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_proquest_journals_1399197097
Other Identifiers
ISSN
0027-8424
E-ISSN
1091-6490
DOI
10.1073/pnas.1309171110
