Pharmacological and genomic profiling identifies NF-[kappa]B-targeted treatment strategies for mantl...
Pharmacological and genomic profiling identifies NF-[kappa]B-targeted treatment strategies for mantle cell lymphoma
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Publisher
New York: Nature Publishing Group
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Language
English
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New York: Nature Publishing Group
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Contents
A screen for compounds that may inhibit the growth of hematological malignancies reveals the specific dependence of some mantle cell lymphoma (MCL) cell lines on canonical or alternative NF-[kappa]B signaling. As also seen in patients, genetic alterations affecting alternative NF-[kappa]B signaling confer insensibility to ibrutinib, a compound that...
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Full title
Pharmacological and genomic profiling identifies NF-[kappa]B-targeted treatment strategies for mantle cell lymphoma
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TN_cdi_proquest_journals_1474887532
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https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_proquest_journals_1474887532
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ISSN
1078-8956
E-ISSN
1546-170X
DOI
10.1038/nm.3435
