Structural and functional in silico analysis of LRRK2 missense substitutions
Structural and functional in silico analysis of LRRK2 missense substitutions
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Publisher
Dordrecht: Springer Netherlands
Journal title
Language
English
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Publisher
Dordrecht: Springer Netherlands
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Scope and Contents
Contents
The
LRRK2
gene (
Leucine
-
Rich Repeat Kinase 2
, PARK8) is mutated in a significant number of cases of autosomal dominant Parkinson’s disease (PD) and in some sporadic cases of late-onset PD. LRRK2 is a large, complex protein that comprises several interaction domains: armadillo, ankyrin, leucine-rich repeats and WD40 domains; tw...
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Full title
Structural and functional in silico analysis of LRRK2 missense substitutions
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Author / Creator
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TN_cdi_proquest_journals_1510744545
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_proquest_journals_1510744545
Other Identifiers
ISSN
0301-4851
E-ISSN
1573-4978
DOI
10.1007/s11033-014-3111-z
