An integrin [beta]3-KRAS-RalB complex drives tumour stemness and resistance to EGFR inhibition
An integrin [beta]3-KRAS-RalB complex drives tumour stemness and resistance to EGFR inhibition
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Author / Creator
Seguin, Laetitia , Kato, Shumei , Franovic, Aleksandra , Camargo, M Fernanda , Lesperance, Jacqueline , Elliott, Kathryn C , Yebra, Mayra , Mielgo, Ainhoa , Lowy, Andrew M , Husain, Hatim , Cascone, Tina , Diao, Lixia , Wang, Jing , Wistuba, Ignacio I , Heymach, John V , Lippman, Scott M , Desgrosellier, Jay S , Anand, Sudarshan , Weis, Sara M and Cheresh, David A
Publisher
London: Nature Publishing Group
Journal title
Language
English
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Publication information
Publisher
London: Nature Publishing Group
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Scope and Contents
Contents
Tumour cells, with stem-like properties, are highly aggressive and often show drug resistance. Here, we reveal that integrin α(v)[beta] serves as a marker of breast, lung and pancreatic carcinomas with stem-like properties that are highly resistant to receptor tyrosine kinase inhibitors such as erlotinib. This was observed in vitro and in mice bear...
Alternative Titles
Full title
An integrin [beta]3-KRAS-RalB complex drives tumour stemness and resistance to EGFR inhibition
Authors, Artists and Contributors
Author / Creator
Kato, Shumei
Franovic, Aleksandra
Camargo, M Fernanda
Lesperance, Jacqueline
Elliott, Kathryn C
Yebra, Mayra
Mielgo, Ainhoa
Lowy, Andrew M
Husain, Hatim
Cascone, Tina
Diao, Lixia
Wang, Jing
Wistuba, Ignacio I
Heymach, John V
Lippman, Scott M
Desgrosellier, Jay S
Anand, Sudarshan
Weis, Sara M
Cheresh, David A
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Primary Identifiers
Record Identifier
TN_cdi_proquest_journals_1520400271
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_proquest_journals_1520400271
Other Identifiers
ISSN
1465-7392
E-ISSN
1476-4679
DOI
10.1038/ncb2953
