Critical role of lysine 134 methylation on histone H2AX for [gamma]-H2AX production and DNA repair
Critical role of lysine 134 methylation on histone H2AX for [gamma]-H2AX production and DNA repair
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London: Nature Publishing Group
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English
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London: Nature Publishing Group
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The presence of phosphorylated histone H2AX (γ-H2AX) is associated with the local activation of DNA-damage repair pathways. Although γ-H2AX deregulation in cancer has previously been reported, the molecular mechanism involved and its relationship with other histone modifications remain largely unknown. Here we find that the histone methyltransferas...
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Critical role of lysine 134 methylation on histone H2AX for [gamma]-H2AX production and DNA repair
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TN_cdi_proquest_journals_1634463414
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https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_proquest_journals_1634463414
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E-ISSN
2041-1723
DOI
10.1038/ncomms6691
