Insulin resistance in brain alters dopamine turnover and causes behavioral disorders
Insulin resistance in brain alters dopamine turnover and causes behavioral disorders
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United States: National Academy of Sciences
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Language
English
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Publisher
United States: National Academy of Sciences
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Significance Both types 1 and 2 diabetes are associated with increased risks of age-related decay in cognitive function and mood disorders, especially depression. Insulin action has been shown to regulate neuronal signaling and plasticity. Here we investigate whether brain-specific knockout of insulin receptor (NIRKO) in mice causes behavioral chan...
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Full title
Insulin resistance in brain alters dopamine turnover and causes behavioral disorders
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TN_cdi_proquest_journals_1665573279
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https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_proquest_journals_1665573279
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ISSN
0027-8424
E-ISSN
1091-6490
DOI
10.1073/pnas.1500877112
