PPAR-[delta] is repressed in Huntington's disease, is required for normal neuronal function and can...
PPAR-[delta] is repressed in Huntington's disease, is required for normal neuronal function and can be targeted therapeutically
About this item
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Author / Creator
Dickey, Audrey S , Pineda, Victor V , Tsunemi, Taiji , Liu, Patrick P , Miranda, Helen C , Gilmore-hall, Stephen K , Lomas, Nicole , Sampat, Kunal R , Buttgereit, Anne , Torres, Mark-joseph Manalang , Flores, April L , Arreola, Martin , Arbez, Nicolas , Akimov, Sergey S , Gaasterland, Terry , Lazarowski, Eduardo R , Ross, Christopher A , Yeo, Gene W , Sopher, Bryce L , Magnuson, Gavin K , Pinkerton, Anthony B , Masliah, Eliezer and La Spada, Albert R
Publisher
New York: Nature Publishing Group
Journal title
Language
English
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Publication information
Publisher
New York: Nature Publishing Group
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More information
Scope and Contents
Contents
Huntington's disease (HD) is a progressive neurodegenerative disorder caused by a CAG trinucleotide repeat expansion in the huntingtin (HTT) gene, which encodes a polyglutamine tract in the HTT protein. We found that peroxisome proliferator-activated receptor delta (PPAR-δ) interacts with HTT and that mutant HTT represses PPAR-δ-mediated transactiv...
Alternative Titles
Full title
PPAR-[delta] is repressed in Huntington's disease, is required for normal neuronal function and can be targeted therapeutically
Authors, Artists and Contributors
Author / Creator
Pineda, Victor V
Tsunemi, Taiji
Liu, Patrick P
Miranda, Helen C
Gilmore-hall, Stephen K
Lomas, Nicole
Sampat, Kunal R
Buttgereit, Anne
Torres, Mark-joseph Manalang
Flores, April L
Arreola, Martin
Arbez, Nicolas
Akimov, Sergey S
Gaasterland, Terry
Lazarowski, Eduardo R
Ross, Christopher A
Yeo, Gene W
Sopher, Bryce L
Magnuson, Gavin K
Pinkerton, Anthony B
Masliah, Eliezer
La Spada, Albert R
Identifiers
Primary Identifiers
Record Identifier
TN_cdi_proquest_journals_1754094695
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_proquest_journals_1754094695
Other Identifiers
ISSN
1078-8956
E-ISSN
1546-170X
DOI
10.1038/nm.4003
