Decreased amyloid-[beta] and increased neuronal hyperactivity by immunotherapy in Alzheimer's models
Decreased amyloid-[beta] and increased neuronal hyperactivity by immunotherapy in Alzheimer's models
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New York: Nature Publishing Group
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Language
English
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New York: Nature Publishing Group
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Among the most promising approaches for treating Alzheimer´s disease is immunotherapy with amyloid-β (Aβ)-targeting antibodies. Using in vivo two-photon imaging in mouse models, we found that two different antibodies to Aβ used for treatment were ineffective at repairing neuronal dysfunction and caused an increase in cortical hyperactivity. This un...
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Decreased amyloid-[beta] and increased neuronal hyperactivity by immunotherapy in Alzheimer's models
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TN_cdi_proquest_journals_1766293181
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https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_proquest_journals_1766293181
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ISSN
1097-6256
E-ISSN
1546-1726
DOI
10.1038/nn.4163
