711. Allele-Specific Silencing of Mutant Huntingtin for Huntington's Disease Therapy
711. Allele-Specific Silencing of Mutant Huntingtin for Huntington's Disease Therapy
About this item
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Publisher
Milwaukee: Elsevier Limited
Journal title
Language
English
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Publication information
Publisher
Milwaukee: Elsevier Limited
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Scope and Contents
Contents
Huntington's disease (HD) is a dominant genetic neurodegenerative disease. Studies in a tetracycline-responsive mouse model showed that continuous expression of the mutant allele is required for the development of behavioral and pathological symptoms; when mutant huntingtin expression was turned off, disease phenotypes resolved. More recently, gene...
Alternative Titles
Full title
711. Allele-Specific Silencing of Mutant Huntingtin for Huntington's Disease Therapy
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TN_cdi_proquest_journals_1792795195
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_proquest_journals_1792795195
Other Identifiers
ISSN
1525-0016
E-ISSN
1525-0024
DOI
10.1016/j.ymthe.2006.08.790
