Mechanism of TAp73 inhibition by [Delta]Np63 and structural basis of p63/p73 hetero-tetramerization
Mechanism of TAp73 inhibition by [Delta]Np63 and structural basis of p63/p73 hetero-tetramerization
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Rome: Nature Publishing Group
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English
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Rome: Nature Publishing Group
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Members of the p53 tumor-suppressor family are expressed as multiple isoforms. Isoforms with an N-terminal transactivation domain are transcriptionally active, while those ones lacking this domain often inhibit the transcriptional activity of other family members. In squamous cell carcinomas, the high expression level of ΔNp63α inhibits the tumor-s...
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Mechanism of TAp73 inhibition by [Delta]Np63 and structural basis of p63/p73 hetero-tetramerization
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TN_cdi_proquest_journals_1841769502
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https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_proquest_journals_1841769502
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1350-9047
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1476-5403
DOI
10.1038/cdd.2016.83
