A natural product inhibits the initiation of [alpha]-synuclein aggregation and suppresses its toxici...
A natural product inhibits the initiation of [alpha]-synuclein aggregation and suppresses its toxicity
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Author / Creator
Perni, Michele , Galvagnion, Céline , Maltsev, Alexander , Meisl, Georg , Müller, Martin BD , Challa, Pavan K , Kirkegaard, Julius B , Flagmeier, Patrick , Cohen, Samuel I A , Cascella, Roberta , Chen, Serene W , Limboker, Ryan , Sormanni, Pietro , Heller, Gabriella T , Aprile, Francesco A , Cremades, Nunilo , Cecchi, Cristina , Chiti, Fabrizio , Nollen, Ellen A A , Knowles, Tuomas P J , Vendruscolo, Michele , Bax, Adriaan , Zasloff, Michael and Dobson, Christopher M
Publisher
Washington: National Academy of Sciences
Journal title
Language
English
Formats
Publication information
Publisher
Washington: National Academy of Sciences
Subjects
More information
Scope and Contents
Contents
The self-assembly of a-synuclein is closely associated with Parkinson's disease and related syndromes. We show that squalamine, a natural product with known anticancer and antiviral activity, dramatically affects a-synuclein aggregation in vitro and in vivo. We elucidate the mechanism of action of squalamine by investigating its interaction with li...
Alternative Titles
Full title
A natural product inhibits the initiation of [alpha]-synuclein aggregation and suppresses its toxicity
Authors, Artists and Contributors
Author / Creator
Galvagnion, Céline
Maltsev, Alexander
Meisl, Georg
Müller, Martin BD
Challa, Pavan K
Kirkegaard, Julius B
Flagmeier, Patrick
Cohen, Samuel I A
Cascella, Roberta
Chen, Serene W
Limboker, Ryan
Sormanni, Pietro
Heller, Gabriella T
Aprile, Francesco A
Cremades, Nunilo
Cecchi, Cristina
Chiti, Fabrizio
Nollen, Ellen A A
Knowles, Tuomas P J
Vendruscolo, Michele
Bax, Adriaan
Zasloff, Michael
Dobson, Christopher M
Identifiers
Primary Identifiers
Record Identifier
TN_cdi_proquest_journals_1876858856
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_proquest_journals_1876858856
Other Identifiers
ISSN
0027-8424
E-ISSN
1091-6490
