Synthesis of phenylpyridine derivatives and their biological evaluation toward dipeptidyl peptidase-...
Synthesis of phenylpyridine derivatives and their biological evaluation toward dipeptidyl peptidase-4
About this item
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Publisher
New York: Springer US
Journal title
Language
English
Formats
Publication information
Publisher
New York: Springer US
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Scope and Contents
Contents
A novel series of pyridine-based derivatives was synthesized and evaluated for their inhibitory activity against dipeptidyl peptidase-4 (DPP4). 5-Aminomethyl-6-(2,4-dichlorophenyl)-4-[(1
H
-1,2,4-triazol-1-yl)methyl]pyridine-2-carboxylic acid was identified as a potent (IC
50
0.57 nM) and selective DPP4 inhibitor (DPP8/DPP4 = 238). A do...
Alternative Titles
Full title
Synthesis of phenylpyridine derivatives and their biological evaluation toward dipeptidyl peptidase-4
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Author / Creator
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Record Identifier
TN_cdi_proquest_journals_1895872836
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_proquest_journals_1895872836
Other Identifiers
ISSN
0009-3122
E-ISSN
1573-8353
DOI
10.1007/s10593-017-2062-4
