Forebrain microglia from wild-type but not adult 5xFAD mice prevent amyloid-[beta] plaque formation...
Forebrain microglia from wild-type but not adult 5xFAD mice prevent amyloid-[beta] plaque formation in organotypic hippocampal slice cultures
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London: Nature Publishing Group
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English
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London: Nature Publishing Group
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The role of microglia in amyloid-β (Aβ) deposition is controversial. In the present study, an organotypic hippocampal slice culture (OHSC) system with an in vivo-like microglial-neuronal environment was used to investigate the potential contribution of microglia to Aβ plaque formation. We found that microglia ingested Aβ, thereby preventing plaque...
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Forebrain microglia from wild-type but not adult 5xFAD mice prevent amyloid-[beta] plaque formation in organotypic hippocampal slice cultures
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TN_cdi_proquest_journals_1899747738
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https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_proquest_journals_1899747738
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E-ISSN
2045-2322
DOI
10.1038/srep14624
