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Phase I dose-escalation study of milciclib in combination with gemcitabine in patients with refracto...

Phase I dose-escalation study of milciclib in combination with gemcitabine in patients with refracto...

https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_proquest_journals_1900488877

Phase I dose-escalation study of milciclib in combination with gemcitabine in patients with refractory solid tumors

About this item

Full title

Phase I dose-escalation study of milciclib in combination with gemcitabine in patients with refractory solid tumors

Publisher

Berlin/Heidelberg: Springer Berlin Heidelberg

Journal title

Cancer chemotherapy and pharmacology, 2017-06, Vol.79 (6), p.1257-1265

Language

English

Formats

Publication information

Publisher

Berlin/Heidelberg: Springer Berlin Heidelberg

More information

Scope and Contents

Contents

Background
This phase I trial evaluated the safety and tolerability of milciclib, an inhibitor of multiple cyclin-dependent kinases and tropomycin receptor kinase A, in combination with gemcitabine in patients with refractory solid tumors.
Design
Sixteen patients were enrolled and treated with milciclib at three dose levels (45 mg/m
2

Alternative Titles

Full title

Phase I dose-escalation study of milciclib in combination with gemcitabine in patients with refractory solid tumors

Identifiers

Primary Identifiers

Record Identifier

TN_cdi_proquest_journals_1900488877

Permalink

https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_proquest_journals_1900488877

Other Identifiers

ISSN

0344-5704

E-ISSN

1432-0843

DOI

10.1007/s00280-017-3303-z

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