Human GLP-1 receptor transmembrane domain structure in complex with allosteric modulators
Human GLP-1 receptor transmembrane domain structure in complex with allosteric modulators
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Song, Gaojie , Yang, Dehua , Wang, Yuxia , de Graaf, Chris , Zhou, Qingtong , Jiang, Shanshan , Liu, Kaiwen , Cai, Xiaoqing , Dai, Antao , Lin, Guangyao , Liu, Dongsheng , Wu, Fan , Wu, Yiran , Zhao, Suwen , Ye, Li , Han, Gye Won , Lau, Jesper , Wu, Beili , Hanson, Michael A. , Liu, Zhi-Jie , Wang, Ming-Wei and Stevens, Raymond C.
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London: Nature Publishing Group UK
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English
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London: Nature Publishing Group UK
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Contents
Crystal structures of the human GLP-1 receptor in complex with two negative allosteric modulators reveal a common binding pocket, and, together with mutagenesis and modelling studies, further our understanding of the receptor activation mechanism.Author: Please check the wording of the following statement, which will appear online only.
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Human GLP-1 receptor transmembrane domain structure in complex with allosteric modulators
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TN_cdi_proquest_journals_1909733952
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https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_proquest_journals_1909733952
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ISSN
0028-0836
E-ISSN
1476-4687
DOI
10.1038/nature22378