Genetic wiring maps of single-cell protein states reveal an off-switch for GPCR signalling
Genetic wiring maps of single-cell protein states reveal an off-switch for GPCR signalling
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London: Nature Publishing Group UK
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Language
English
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Publisher
London: Nature Publishing Group UK
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Contents
Random mutagenesis in haploid human cells coupled to quantitative protein measurements with different antibodies is used as a readout for individual cellular phenotypes.
Mapping protein states
Genetic perturbation approaches have been used to study the regulatory networks of human cells, but many cellular events don't affect traditional assay...
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Full title
Genetic wiring maps of single-cell protein states reveal an off-switch for GPCR signalling
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TN_cdi_proquest_journals_1909737373
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https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_proquest_journals_1909737373
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ISSN
0028-0836
E-ISSN
1476-4687
DOI
10.1038/nature22376
