Defective dendritic cell migration and activation of adaptive immunity in PI3K[gamma]-deficient mice
Defective dendritic cell migration and activation of adaptive immunity in PI3K[gamma]-deficient mice
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New York: Springer Nature B.V
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Language
English
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New York: Springer Nature B.V
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Gene-targeted mice were used to evaluate the role of the gamma isoform of phosphoinositide 3-kinase (PI3Kgamma) in dendritic cell (DC) migration and induction of specific T-cell-mediated immune responses. DC obtained from PI3Kgamma-/- mice showed a reduced ability to respond to chemokines in vitro and ex vivo and to travel to draining lymph nodes u...
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Full title
Defective dendritic cell migration and activation of adaptive immunity in PI3K[gamma]-deficient mice
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TN_cdi_proquest_journals_195271292
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https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_proquest_journals_195271292
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ISSN
0261-4189
E-ISSN
1460-2075
DOI
10.1038/sj.emboj.7600361
