Mitochondrial complex I inhibition is not required for dopaminergic neuron death induced by rotenone...
Mitochondrial complex I inhibition is not required for dopaminergic neuron death induced by rotenone, MPP⁺, or paraquat
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United States: National Academy of Sciences
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English
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United States: National Academy of Sciences
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Inhibition of mitochondrial complex I is one of the leading hypotheses for dopaminergic neuron death associated with Parkinson's disease (PD). To test this hypothesis genetically, we used a mouse strain lacking functional Ndufs4, a gene encoding a subunit required for complete assembly and function of complex I. Deletion of the Ndufs4 gene abolishe...
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Full title
Mitochondrial complex I inhibition is not required for dopaminergic neuron death induced by rotenone, MPP⁺, or paraquat
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TN_cdi_proquest_journals_201325335
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https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_proquest_journals_201325335
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ISSN
0027-8424
E-ISSN
1091-6490
DOI
10.1073/pnas.0807581105
