Polyglutamine Aggregation Nucleation: Thermodynamics of a Highly Unfavorable Protein Folding Reactio...
Polyglutamine Aggregation Nucleation: Thermodynamics of a Highly Unfavorable Protein Folding Reaction
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Publisher
United States: National Academy of Sciences
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Language
English
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Publisher
United States: National Academy of Sciences
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Contents
Polyglutamine (polyGln) aggregation is implicated in the disease progression of Huntington's disease and other expanded CAG repeat diseases. PolyGIn aggregation in vitro follows a simple nucleated growth polymerization pathway without apparent complications such as populated intermediates, alternative assembly pathways, or secondary nucleation phen...
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Full title
Polyglutamine Aggregation Nucleation: Thermodynamics of a Highly Unfavorable Protein Folding Reaction
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TN_cdi_proquest_journals_201356551
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https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_proquest_journals_201356551
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ISSN
0027-8424
E-ISSN
1091-6490
DOI
10.1073/pnas.0501651102
