Defective Cardiovascular Development and Elevated Cyclin E and Notch Proteins in Mice Lacking the Fb...
Defective Cardiovascular Development and Elevated Cyclin E and Notch Proteins in Mice Lacking the Fbw7 F-Box Protein
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United States: National Academy of Sciences
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Language
English
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United States: National Academy of Sciences
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Contents
The mammalian F-box protein Fbw7 and its Caenorhabditis elegans counterpart Sel-10 have been implicated in the ubiquitin-mediated turnover of cyclin E as well as the Notch/Lin-12 family of transcriptional activators. Both unregulated Notch and cyclin E promote tumorigenesis, and inactivating mutations in human Fbw7 suggest that it may be a tumor su...
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Full title
Defective Cardiovascular Development and Elevated Cyclin E and Notch Proteins in Mice Lacking the Fbw7 F-Box Protein
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TN_cdi_proquest_journals_201364744
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https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_proquest_journals_201364744
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ISSN
0027-8424
E-ISSN
1091-6490
DOI
10.1073/pnas.0307875101
