WNK3 Bypasses the Tonicity Requirement for K-Cl Cotransporter Activation via a Phosphatase-Dependent...
WNK3 Bypasses the Tonicity Requirement for K-Cl Cotransporter Activation via a Phosphatase-Dependent Pathway
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United States: National Academy of Sciences
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Language
English
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United States: National Academy of Sciences
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SLC12A cation/Cl⁻ cotransporters are mutated in human disease, are targets of diuretics, and are collectively involved in the regulation of cell volume, neuronal excitability, and blood pressure. This gene family has two major branches with different physiological functions and inverse regulation: K-CI cotransporters (KCC1-KCC4) mediate cellular CI...
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WNK3 Bypasses the Tonicity Requirement for K-Cl Cotransporter Activation via a Phosphatase-Dependent Pathway
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TN_cdi_proquest_journals_201382595
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https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_proquest_journals_201382595
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ISSN
0027-8424
E-ISSN
1091-6490
DOI
10.1073/pnas.0510947103