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WNK3 Bypasses the Tonicity Requirement for K-Cl Cotransporter Activation via a Phosphatase-Dependent...

WNK3 Bypasses the Tonicity Requirement for K-Cl Cotransporter Activation via a Phosphatase-Dependent...

https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_proquest_journals_201382595

WNK3 Bypasses the Tonicity Requirement for K-Cl Cotransporter Activation via a Phosphatase-Dependent Pathway

About this item

Full title

WNK3 Bypasses the Tonicity Requirement for K-Cl Cotransporter Activation via a Phosphatase-Dependent Pathway

Publisher

United States: National Academy of Sciences

Journal title

Proceedings of the National Academy of Sciences - PNAS, 2006-02, Vol.103 (6), p.1976-1981

Language

English

Formats

Publication information

Publisher

United States: National Academy of Sciences

More information

Scope and Contents

Contents

SLC12A cation/Cl⁻ cotransporters are mutated in human disease, are targets of diuretics, and are collectively involved in the regulation of cell volume, neuronal excitability, and blood pressure. This gene family has two major branches with different physiological functions and inverse regulation: K-CI cotransporters (KCC1-KCC4) mediate cellular CI...

Alternative Titles

Full title

WNK3 Bypasses the Tonicity Requirement for K-Cl Cotransporter Activation via a Phosphatase-Dependent Pathway

Identifiers

Primary Identifiers

Record Identifier

TN_cdi_proquest_journals_201382595

Permalink

https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_proquest_journals_201382595

Other Identifiers

ISSN

0027-8424

E-ISSN

1091-6490

DOI

10.1073/pnas.0510947103

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