Mitaplatin, a potent fusion of cisplatin and the orphan drug dichloroacetate
Mitaplatin, a potent fusion of cisplatin and the orphan drug dichloroacetate
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Full title
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Publisher
United States: National Academy of Sciences
Journal title
Language
English
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Publisher
United States: National Academy of Sciences
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Scope and Contents
Contents
The unique glycolytic metabolism of most solid tumors, known as the Warburg effect, is associated with resistance to apoptosis that enables cancer cells to survive. Dichloroacetate (DCA) is an anticancer agent that can reverse the Warburg effect by inhibiting a key enzyme in cancer cells, pyruvate dehydrogenase kinase (PDK), that is required for th...
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Full title
Mitaplatin, a potent fusion of cisplatin and the orphan drug dichloroacetate
Authors, Artists and Contributors
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Record Identifier
TN_cdi_proquest_journals_201398733
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_proquest_journals_201398733
Other Identifiers
ISSN
0027-8424
E-ISSN
1091-6490
DOI
10.1073/pnas.0912276106
